Antagonism of miR-21 Reverses Epithelial-Mesenchymal Transition and Cancer Stem Cell Phenotype through AKT/ERK1/2 Inactivation by Targeting PTEN

BACKGROUND: Accumulating evidence suggested that epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) characteristics, both of which contribute to tumor invasion and metastasis, are interrelated with miR-21. MiR-21 is one of the important microRNAs associated with tumor progression and...

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Detalhes bibliográficos
Main Authors: Han, Mingli, Liu, Manran, Wang, Yimeng, Chen, Xin, Xu, Jianli, Sun, Yan, Zhao, Liuyang, Qu, Hongbo, Fan, Yuanming, Wu, Chengyi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382593/
https://ncbi.nlm.nih.gov/pubmed/22761812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039520
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