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Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression

The DNA damage response comprises DNA repair, cell-cycle checkpoint control, and DNA damage-induced apoptosis that collectively promote genomic integrity and suppress tumorigenesis. Previously, we have shown that the Chk2 kinase functions independently of the Mre11 complex (Mre11, Rad50, and Nbs1) a...

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Detalhes bibliográficos
Main Authors: Foster, Steven S., De, Saurav, Johnson, Linda K., Petrini, John H. J., Stracker, Travis H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382548/
https://ncbi.nlm.nih.gov/pubmed/22670056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120476109
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