The novel chromogranin A-derived serpinin and pyroglutaminated serpinin peptides are positive cardiac β-adrenergic-like inotropes

Three forms of serpinin peptides, serpinin (Ala26Leu), pyroglutaminated (pGlu)-serpinin (pGlu23Leu), and serpinin-Arg-Arg-Gly (Ala29Gly), are derived from cleavage at pairs of basic residues in the highly conserved C terminus of chromogranin A (CgA). Serpinin induces PN-1 expression in neuroendocrin...

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Autori principali: Tota, Bruno, Gentile, Stefano, Pasqua, Teresa, Bassino, Eleonora, Koshimizu, Hisatsugu, Cawley, Niamh X., Cerra, Maria C., Loh, Y. Peng, Angelone, Tommaso
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2012
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382102/
https://ncbi.nlm.nih.gov/pubmed/22459152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-201111
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