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Modifying the genetic code: Converting nonsense codons into sense codons by targeted pseudouridylation
All three translation termination codons, or nonsense codons, contain a uridine residue at the first position of the codon(1–3). Here, we demonstrate that pseudouridylation [conversion of uridine into pseudouridine (Ψ) (4)] of nonsense codons suppresses translation termination both in vitro and in v...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3381908/ https://ncbi.nlm.nih.gov/pubmed/21677757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10165 |
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