An S-Opsin Knock-In Mouse (F81Y) Reveals a Role for the Native Ligand 11-cis-Retinal in Cone Opsin Biosynthesis

In absence of their natural ligand, 11-cis-retinal, cone opsin G-protein-coupled receptors fail to traffic normally, a condition associated with photoreceptor degeneration and blindness. We created a mouse with a point mutation (F81Y) in cone S-opsin. As expected, cones with this knock-in mutation r...

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Bibliografiske detaljer
Main Authors: Insinna, Christine, Daniele, Lauren L., Davis, Jason A., Larsen, DeLaine D., Kuemmel, Colleen, Wang, Jinhua, Nikonov, Sergei S., Knox, Barry E., Pugh, Edward N.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381355/
https://ncbi.nlm.nih.gov/pubmed/22674284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0131-12.2012
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