Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors†

[Image: see text] Mycobacterium tuberculosis glutamine synthetase (MtGS) is a promising target for antituberculosis drug discovery. In a recent high-throughput screening study we identified several classes of MtGS inhibitors targeting the ATP-binding site. We now explore one of these classes, the 2-...

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Main Authors: Gising, Johan, Nilsson, Mikael T., Odell, Luke R., Yahiaoui, Samir, Lindh, Martin, Iyer, Harini, Sinha, Achyut M., Srinivasa, Bachally R., Larhed, Mats, Mowbray, Sherry L., Karlén, Anders
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2012
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381009/
https://ncbi.nlm.nih.gov/pubmed/22369127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201212h
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