Isolation of Monoclonal Antibodies with Predetermined Conformational Epitope Specificity

Existing technologies allow isolating antigen-specific monoclonal antibodies (mAbs) from B cells. We devised a direct approach to isolate mAbs with predetermined conformational epitope specificity, using epitope mimetics (mimotopes) that reflect the three-dimensional structure of given antigen subdo...

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Hauptverfasser: Sholukh, Anton M., Mukhtar, Muhammad M., Humbert, Michael, Essono, Sosthène S., Watkins, Jennifer D., Vyas, Hemant K., Shanmuganathan, Vivekanandan, Hemashettar, Girish, Kahn, Maria, Hu, Shiu-Lok, Montefiori, David C., Polonis, Victoria R., Schur, Peter H., Ruprecht, Ruth M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380854/
https://ncbi.nlm.nih.gov/pubmed/22737224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038943
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