Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation

Eukaryotic RNA polymerase II (Pol II) has evolved an array of heptad repeats with the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 at the carboxy-terminal domain (CTD) of the large subunit (Rpb1). Differential phosphorylation of Ser2, Ser5, and Ser7 in the 5′ and 3′ regions of genes coordin...

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Autors principals: Hintermair, Corinna, Heidemann, Martin, Koch, Frederic, Descostes, Nicolas, Gut, Marta, Gut, Ivo, Fenouil, Romain, Ferrier, Pierre, Flatley, Andrew, Kremmer, Elisabeth, Chapman, Rob D, Andrau, Jean-Christophe, Eick, Dirk
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380212/
https://ncbi.nlm.nih.gov/pubmed/22549466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.123
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