A Monoclonal Antibody-GDNF Fusion Protein Is Not Neuroprotective and Is Associated with Proliferative Pancreatic Lesions in Parkinsonian Monkeys

Glial cell line derived neurotrophic factor (GDNF) is a neurotrophic factor that has neuroprotective effects in animal models of Parkinson’s disease (PD) and has been proposed as a PD therapy. GDNF does not cross the blood brain barrier (BBB), and requires direct intracerebral delivery to be effecti...

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Autores principales: Ohshima-Hosoyama, Sachiko, Simmons, Heather A., Goecks, Nichole, Joers, Valerie, Swanson, Christine R., Bondarenko, Viktoriya, Velotta, Rebecca, Brunner, Kevin, Wood, Laura D., Hruban, Ralph H., Emborg, Marina E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380056/
https://ncbi.nlm.nih.gov/pubmed/22745701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039036
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