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An Intron-Retaining Splice Variant of Human Cyclin A2, Expressed in Adult Differentiated Tissues, Induces a G1/S Cell Cycle Arrest In Vitro

BACKGROUND: Human cyclin A2 is a key regulator of S phase progression and entry into mitosis. Alternative splice variants of the G1 and mitotic cyclins have been shown to interfere with full-length cyclin functions to modulate cell cycle progression and are therefore likely to play a role in differe...

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Autors principals: Honda, Arata, Valogne, Yannick, Bou Nader, Myriam, Bréchot, Christian, Faivre, Jamila
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379989/
https://ncbi.nlm.nih.gov/pubmed/22745723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039249
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