Polyadenylation helps regulate functional tRNA levels in Escherichia coli

Here we demonstrate a new regulatory mechanism for tRNA processing in Escherichia coli whereby RNase T and RNase PH, the two primary 3′ → 5′ exonucleases involved in the final step of 3′-end maturation, compete with poly(A) polymerase I (PAP I) for tRNA precursors in wild-type cells. In the absence...

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Main Authors: Mohanty, Bijoy K., Maples, Valerie F., Kushner, Sidney R.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Nucleic Acid Enzymes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378859/
https://ncbi.nlm.nih.gov/pubmed/22287637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks006
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