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Spontaneous Formation of Tumorigenic Hybrids between Breast Cancer and Multipotent Stromal Cells Is a Source of Tumor Heterogeneity

Breast cancer progression involves cancer cell heterogeneity, with generation of invasive/metastatic breast cancer cells within populations of nonmetastatic cells of the primary tumor. Sequential genetic mutations, epithelial-to-mesenchymal transition, interaction with local stroma, and formation of...

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Autors principals: Rappa, Germana, Mercapide, Javier, Lorico, Aurelio
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378856/
https://ncbi.nlm.nih.gov/pubmed/22542847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.02.020
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