Mucin Muc2 Deficiency and Weaning Influences the Expression of the Innate Defense Genes Reg3β, Reg3γ and Angiogenin-4

BACKGROUND: Mucin Muc2 is the structural component of the intestinal mucus layer. Absence of Muc2 leads to loss of this layer allowing direct bacterial-epithelial interactions. We hypothesized that absence of the mucus layer leads to increased expression of innate defense peptides. Specifically, we...

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Main Authors: Burger-van Paassen, Nanda, Loonen, Linda M. P., Witte-Bouma, Janneke, Korteland-van Male, Anita M., de Bruijn, Adrianus C. J. M., van der Sluis, Maria, Lu, Peng, Van Goudoever, Johannes B., Wells, Jerry M., Dekker, Jan, Van Seuningen, Isabelle, Renes, Ingrid B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378615/
https://ncbi.nlm.nih.gov/pubmed/22723890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038798
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