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Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases
Somatic missense mutations in PIK3CA, which encodes the p110α catalytic subunit of phosphoinositide 3-kinases (PI3Ks), occur frequently in human cancers. Activating mutations spread across multiple domains, some of which are located at inhibitory contact sites formed with the regulatory subunit p85α...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378484/ https://ncbi.nlm.nih.gov/pubmed/22120714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.532 |
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