Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes

We examined the impact of early diabetes on the circulating and kidney renin-angiotensin system (RAS) in male and female mRen2.Lewis (mRen2) hypertensive rats. Diabetes (DB) was induced by streptozotocin (STZ; 65 mg/kg) at 11 wk of age for 4 wk without insulin replacement. Systolic blood pressures w...

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Auteurs principaux: Yamaleyeva, Liliya M., Gilliam-Davis, Shea, Almeida, Igor, Brosnihan, K. Bridget, Lindsey, Sarah H., Chappell, Mark C.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2012
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378178/
https://ncbi.nlm.nih.gov/pubmed/22378820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00656.2011
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