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Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins
Norepinephrine has for many years been known to have three major effects on the pancreatic β-cell which lead to the inhibition of insulin release. These are activation of K(+) channels to hyperpolarize the cell and prevent the gating of voltage-dependent Ca(2+) channels that increase intracellular C...
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Physiological Society
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378079/ https://ncbi.nlm.nih.gov/pubmed/22492651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00282.2011 |
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