Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy

Multiple system atrophy (MSA) is a progressive late onset neurodegenerative α-synucleinopathy with unclear pathogenesis. Recent genetic and pathological studies support a central role of α-synuclein (αSYN) in MSA pathogenesis. Oligodendroglial cytoplasmic inclusions of fibrillar αSYN and dysfunction...

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Autori principali: Stefanova, Nadia, Kaufmann, Walter A., Humpel, Christian, Poewe, Werner, Wenning, Gregor K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer-Verlag 2012
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377902/
https://ncbi.nlm.nih.gov/pubmed/22491959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-012-0977-5
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