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Amyloid Deposition and Advanced Age Fails to Induce Alzheimer’s Type Progression in a Double Knock-In Mouse Model
It has been challenging to develop transgenic and gene-targeted mouse models that recapitulate all of the neuropathological features of Alzheimer’s disease (AD). For example, in the APP/PS-1 double knock-in mutant mouse (DKI), frank neurodegeneration is not observed at middle age and synapse loss is...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
JKL International LLC
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3377826/ https://ncbi.nlm.nih.gov/pubmed/22724075 |
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