Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a Novel Anti-Inflammatory Drug Candidate

BACKGROUND: 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole (DIC) is a five-membered heterocyclic compound containing a N-O bond. The anti-inflammatory effects of this compound were studied both in vitro and in vivo. PRINCIPAL FINDINGS: DIC effectively decreased TNF-α and IL-6 release from LP...

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Main Authors: Vicentino, Amanda Roberta Revoredo, Carneiro, Vitor Coutinho, Amarante, Anderson de Mendonça, Benjamim, Claudia Farias, de Aguiar, Alcino Palermo, Fantappié, Marcelo Rosado
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377599/
https://ncbi.nlm.nih.gov/pubmed/22723938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039104
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