Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers

Germ-line mutations in the BRCA1 gene strongly predispose women to breast cancer (lifetime risk up to 80%). Furthermore, the BRCA1 protein is absent or present at very low levels in about one third of sporadic breast cancers. However, the mechanisms underlying BRCA1 somatic inactivation appear multi...

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Bibliographic Details
Main Authors: Garcia, Amandine I, Buisson, Monique, Bertrand, Pascale, Rimokh, Ruth, Rouleau, Etienne, Lopez, Bernard S, Lidereau, Rosette, Mikaélian, Ivan, Mazoyer, Sylvie
Format: Artigo
Language:Inglês
Published: WILEY-VCH Verlag 2011
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377076/
https://ncbi.nlm.nih.gov/pubmed/21472990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100136
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