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Modulation of DNA repair genes induced by TLR9 agonists: A strategy to eliminate “altered” cells?
We provided evidence that the TLR9 engagement of innate immune cells present in the tumor microenvironment by CpG-oligodeoxynucleotide (CpG-ODN) induces down-modulation of DNA repair gene expression in tumor cells, sensitizing cancer cells to DNA-damaging chemotherapy. These findings expand the bene...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Landes Bioscience
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3377000/ https://ncbi.nlm.nih.gov/pubmed/22720263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.1.2.18343 |
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