Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome

Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome, which is characterized by cleft palate and severe defects of the skin, is an autosomal dominant disorder caused by mutations in the gene encoding transcription factor p63. Here, we report the generation of a knock-in mouse model for...

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Detalhes bibliográficos
Main Authors: Ferone, Giustina, Thomason, Helen A, Antonini, Dario, De Rosa, Laura, Hu, Bing, Gemei, Marica, Zhou, Huiqing, Ambrosio, Raffaele, Rice, David P, Acampora, Dario, van Bokhoven, Hans, Del Vecchio, Luigi, Koster, Maranke I, Tadini, Gianluca, Spencer-Dene, Bradley, Dixon, Michael, Dixon, Jill, Missero, Caterina
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376849/
https://ncbi.nlm.nih.gov/pubmed/22247000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100199
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