Activation of the Orexin 1 Receptor is a Critical Component of CO(2)-Mediated Anxiety and Hypertension but not Bradycardia

Acute hypercapnia (elevated arterial CO(2)/H(+)) is a suffocation signal that is life threatening and rapidly mobilizes adaptive changes in breathing and behavioral arousal in order to restore acid-base homeostasis. Severe hypercapnia, seen in respiratory disorders (eg, asthma or bronchitis, chronic...

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Autores principales: Johnson, Philip L, Samuels, Brian C, Fitz, Stephanie D, Lightman, Stafford L, Lowry, Christopher A, Shekhar, Anantha
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376323/
https://ncbi.nlm.nih.gov/pubmed/22453138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.38
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