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Substrate and Enzyme Functional Groups Contribute to Translational Quality Control by Bacterial Prolyl-tRNA Synthetase

Aminoacyl-tRNA synthetases activate specific amino acid substrates and attach them via an ester linkage to cognate tRNA molecules. In addition to cognate proline, prolyl-tRNA synthetase (ProRS) can activate cysteine and alanine and misacylate tRNA(Pro). Editing of the misacylated aminoacyl-tRNA is r...

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Bibliografske podrobnosti
Main Authors: Kumar, Sandeep, Das, Mom, Hadad, Christopher M., Musier-Forsyth, Karin
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376218/
https://ncbi.nlm.nih.gov/pubmed/22458656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp300845h
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