A Novel Chromone Derivative with Anti-Inflammatory Property via Inhibition of ROS-Dependent Activation of TRAF6-ASK1-p38 Pathway

The p38 MAPK signaling pathway plays a pivotal role in inflammation. Targeting p38 MAPK may be a potential strategy for the treatment of inflammatory diseases. In the present study, we show that a novel chromone derivative, DCO-6, significantly reduced lipopolysaccharide (LPS)-induced production of...

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Detalhes bibliográficos
Main Authors: Liu, Hailiang, Xu, Rui, Feng, Lili, Guo, Wenjie, Cao, Ning, Qian, Cheng, Teng, Peng, Wang, Lu, Wu, Xuefeng, Sun, Yang, Li, Jianxin, Shen, Yan, Xu, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376149/
https://ncbi.nlm.nih.gov/pubmed/22720096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037168
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