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Secreted Phospholipase A2 Involvement in Neurodegeneration: Differential Testing of Prosurvival and Anti-Inflammatory Effects of Enzyme Inhibition

There is increased interest in the contribution of secreted phospholipase A2 (sPLA2) enzymes to neurodegenerative diseases. Systemic treatment with the nonapeptide CHEC-9, a broad spectrum uncompetitive inhibitor of sPLA2, has been shown previously to inhibit neuron death and aspects of the inflamma...

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Hlavní autoři: Chen, Shuyan, Yao, Lihua, Cunningham, Timothy J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376100/
https://ncbi.nlm.nih.gov/pubmed/22720084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039257
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