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The Rd8 Mutation of the Crb1 Gene Is Present in Vendor Lines of C57BL/6N Mice and Embryonic Stem Cells, and Confounds Ocular Induced Mutant Phenotypes

PURPOSE. We noted an unexpected inheritance pattern of lesions in several strains of gene-manipulated mice with ocular phenotypes. The lesions, which appeared at various stages of backcross to C57BL/6, bore resemblance to the rd8 retinal degeneration phenotype. We set out to examine the prevalence o...

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Autores principales: Mattapallil, Mary J., Wawrousek, Eric F., Chan, Chi-Chao, Zhao, Hui, Roychoudhury, Jayeeta, Ferguson, Thomas A., Caspi, Rachel R.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376073/
https://ncbi.nlm.nih.gov/pubmed/22447858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-9662
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