Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells

Accumulation of palmitic acid (PA) in cells from nonadipose tissues is known to induce lipotoxicity resulting in cellular dysfunction and death. The exact molecular pathways of PA-induced cell death are still mysterious. Here, we show that PA triggers autophagy, which did not counteract but in contr...

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Main Authors: Khan, Muhammad Jadoon, Rizwan Alam, Muhammad, Waldeck-Weiermair, Markus, Karsten, Felix, Groschner, Lukas, Riederer, Monika, Hallström, Seth, Rockenfeller, Patrick, Konya, Viktoria, Heinemann, Akos, Madeo, Frank, Graier, Wolfgang F., Malli, Roland
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375534/
https://ncbi.nlm.nih.gov/pubmed/22556413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.319129
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