Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells

Accumulation of palmitic acid (PA) in cells from nonadipose tissues is known to induce lipotoxicity resulting in cellular dysfunction and death. The exact molecular pathways of PA-induced cell death are still mysterious. Here, we show that PA triggers autophagy, which did not counteract but in contr...

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Detalhes bibliográficos
Main Authors: Khan, Muhammad Jadoon, Rizwan Alam, Muhammad, Waldeck-Weiermair, Markus, Karsten, Felix, Groschner, Lukas, Riederer, Monika, Hallström, Seth, Rockenfeller, Patrick, Konya, Viktoria, Heinemann, Akos, Madeo, Frank, Graier, Wolfgang F., Malli, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375534/
https://ncbi.nlm.nih.gov/pubmed/22556413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.319129
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