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Younger Genes Are Less Likely to Be Essential than Older Genes, and Duplicates Are Less Likely to Be Essential than Singletons of the Same Age

Recently duplicated genes are believed to often overlap in function and expression. A priori, they are thus less likely to be essential. Although this was indeed observed in yeast, mouse singletons and duplicates were reported to be equally often essential. This contradiction can only partly be expl...

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Detalhes bibliográficos
Main Authors: Chen, Wei-Hua, Trachana, Kalliopi, Lercher, Martin J., Bork, Peer
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375470/
https://ncbi.nlm.nih.gov/pubmed/22319151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mss014
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