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(Z)-1-Aryl-3-arylamino-2-propen-1-ones, Highly Active Stimulators of Tubulin Polymerization: Synthesis, Structure Activity Relationship (SAR), Tubulin Polymerization and Cell Growth Inhibition Studies
Tubulin, the major structural component of microtubules, is a target for the development of anticancer agents. A series of (Z)-1-Aryl-3-arylamino-2-propen-1-one (10) were synthesized and evaluated for anti-proliferative activity in cell based assay. The most active compound (Z)-1-(2- bromo-3,4,5-tri...
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Hlavní autoři: | , , , , , , , , |
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Médium: | Artigo |
Jazyk: | Inglês |
Vydáno: |
2012
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Témata: | |
On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3375384/ https://ncbi.nlm.nih.gov/pubmed/22587519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300176j |
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