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(Z)-1-Aryl-3-arylamino-2-propen-1-ones, Highly Active Stimulators of Tubulin Polymerization: Synthesis, Structure Activity Relationship (SAR), Tubulin Polymerization and Cell Growth Inhibition Studies

Tubulin, the major structural component of microtubules, is a target for the development of anticancer agents. A series of (Z)-1-Aryl-3-arylamino-2-propen-1-one (10) were synthesized and evaluated for anti-proliferative activity in cell based assay. The most active compound (Z)-1-(2- bromo-3,4,5-tri...

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Autors principals: Reddy, M.V. Ramana, Akula, Balaiah, Cosenza, Stephen C, Lee, Clement M, Mallireddigari, Muralidhar R, Pallela, Venkat R, Subbaiah, DRC Venkata, Udofa, Andrew, Reddy, E. Premkumar
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375384/
https://ncbi.nlm.nih.gov/pubmed/22587519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300176j
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