DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity

BACKGROUND: Histone modifications and DNA methylation are two major factors in epigenetic phenomenon. Unlike the histone deacetylase inhibitors, which are known to exert radiosensitizing effects, there have only been a few studies thus far concerning the role of DNA methyltransferase (DNMT) inhibito...

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Bibliografiske detaljer
Main Authors: Kim, Hak Jae, Kim, Jin Ho, Chie, Eui Kyu, Da Young, Park, Kim, In Ah, Kim, Il Han
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375186/
https://ncbi.nlm.nih.gov/pubmed/22429326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-7-39
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