Age-Related Disruption of Steady-State Thymic Medulla Provokes Autoimmune Phenotype via Perturbing Negative Selection

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• Thymic involution beyond T-cell insufficiency
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• Morphogenesis and maintenance of the 3D-thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium
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• Two subsets of epithelial cells in the thymic medulla
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• Targeted deletion of c-Met in thymic epithelial cells leads to an autoimmune phenotype
  Bằng: Su, Min, et al.
  Được phát hành: (2017)