Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer

The CXC chemokine interleukin-8 (IL-8) is an angiogenic growth factor that is overexpressed in various cancers, including non-small cell lung cancer (NSCLC). Previously, IL-8 was shown as a transcriptional target of RAS signaling, raising the possibility of its role in oncogenic KRAS-driven NSCLC. U...

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Detalhes bibliográficos
Main Authors: Sunaga, Noriaki, Imai, Hisao, Shimizu, Kimihiro, Shames, David S., Kakegawa, Seiichi, Girard, Luc, Sato, Mitsuo, Kaira, Kyoichi, Ishizuka, Tamotsu, Gazdar, Adi F., Minna, John D., Mori, Masatomo
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374723/
https://ncbi.nlm.nih.gov/pubmed/21544811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.26164
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