Intracellular Pathogen Leishmania donovani Activates Hypoxia Inducible Factor-1 by Dual Mechanism for Survival Advantage within Macrophage

Recent evidence established a crucial role for mammalian oxygen sensing transcription factor hypoxia inducible factor-1 (HIF-1) in innate immunity against intracellular pathogens. In response to most of these pathogens host phagocytes increase transcription of HIF-1α, the regulatory component of HIF...

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Main Authors: Singh, Amit Kumar, Mukhopadhyay, Chaitali, Biswas, Sudipta, Singh, Vandana Kumari, Mukhopadhyay, Chinmay K.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373497/
https://ncbi.nlm.nih.gov/pubmed/22701652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038489
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