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Gene–environment interaction testing in family-based association studies with phenotypically ascertained samples: a causal inference approach
We propose a method for testing gene–environment (G × E) interactions on a complex trait in family-based studies in which a phenotypic ascertainment criterion has been imposed. This novel approach employs G-estimation, a semiparametric estimation technique from the causal inference literature, to av...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372944/ https://ncbi.nlm.nih.gov/pubmed/22084302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxr035 |
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