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Gene–environment interaction testing in family-based association studies with phenotypically ascertained samples: a causal inference approach

We propose a method for testing gene–environment (G × E) interactions on a complex trait in family-based studies in which a phenotypic ascertainment criterion has been imposed. This novel approach employs G-estimation, a semiparametric estimation technique from the causal inference literature, to av...

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Autori principali: Fardo, David W., Liu, Jinze, Demeo, Dawn L., Silverman, Edwin K., Vansteelandt, Stijn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372944/
https://ncbi.nlm.nih.gov/pubmed/22084302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxr035
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