Hydrogen sulphide-releasing diclofenac derivatives inhibit breast cancer-induced osteoclastogenesis in vitro and prevent osteolysis ex vivo

BACKGROUND AND PURPOSE: Hydrogen sulphide (H(2)S) and prostaglandins are both involved in inflammation, cancer and bone turnover, and non-steroidal anti-inflammatory drugs (NSAIDs) and H(2)S donors exhibit anti-inflammatory and anti-tumour properties. H(2)S-releasing diclofenac (S-DCF) derivatives a...

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Autori principali: Frantzias, J, Logan, JG, Mollat, P, Sparatore, A, Del Soldato, P, Ralston, SH, Idris, AI
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2012
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372840/
https://ncbi.nlm.nih.gov/pubmed/21955294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01704.x
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