Different in vitro and in vivo profiles of substituted 3-aminopropylphosphinate and 3-aminopropyl(methyl)phosphinate GABA(B) receptor agonists as inhibitors of transient lower oesophageal sphincter relaxation

BACKGROUND AND PURPOSE: Gastro-oesophageal reflux is predominantly caused by transient lower oesophageal sphincter relaxation (TLOSR) and GABA(B) receptor stimulation inhibits TLOSR. Lesogaberan produces fewer CNS side effects than baclofen, which has been attributed to its affinity for the GABA tra...

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Detalhes bibliográficos
Main Authors: Lehmann, A, Antonsson, M, Aurell-Holmberg, A, Blackshaw, LA, Brändén, L, Elebring, T, Jensen, J, Kärrberg, L, Mattsson, JP, Nilsson, K, Oja, SS, Saransaari, P, von Unge, S
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372828/
https://ncbi.nlm.nih.gov/pubmed/21950457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01682.x
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