Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide

BACKGROUND AND PURPOSE: Inhaled corticosteroids (ICS) are the cornerstone of asthma pharmacotherapy and, acting via the glucocorticoid receptor (GR), reduce inflammatory gene expression. While this is often attributed to a direct inhibitory effect of the GR on inflammatory gene transcription, cortic...

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Main Authors: Kelly, MM, King, EM, Rider, CF, Gwozd, C, Holden, NS, Eddleston, J, Zuraw, B, Leigh, R, O'Byrne, PM, Newton, R
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2012
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372826/
https://ncbi.nlm.nih.gov/pubmed/21827450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01620.x
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