Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice

BACKGROUND AND PURPOSE: Emerging evidence implicates a role for toll-like receptor 4 (TLR4) in the CNS effects of alcohol. The aim of the current study was to determine whether TLR4–MyD88-dependent signalling is involved in the acute behavioural actions of alcohol and if alcohol can activate TLR4-do...

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Detalhes bibliográficos
Main Authors: Wu, Yue, Lousberg, Erin L, Moldenhauer, Lachlan M, Hayball, John D, Coller, Janet K, Rice, Kenner C, Watkins, Linda R, Somogyi, Andrew A, Hutchinson, Mark R
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372718/
https://ncbi.nlm.nih.gov/pubmed/21955045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01572.x
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