Human Embryonic Stem Cells have Constitutively Active Bax at the Golgi and are Primed to Undergo Rapid Apoptosis

Human embryonic stem (hES) cells activate a rapid apoptotic response after DNA damage but the underlying mechanisms are unknown. A critical mediator of apoptosis is Bax, which is reported to become active and translocate to the mitochondria only after apoptotic stimuli. Here we show that undifferent...

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Bibliographic Details
Main Authors: Dumitru, Raluca, Gama, Vivian, Fagan, B. Matthew, Bower, Jacquelyn J., Swahari, Vijay, Pevny, Larysa H., Deshmukh, Mohanish
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372694/
https://ncbi.nlm.nih.gov/pubmed/22560721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.04.002
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