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Nanoscaled buffering zone of charged (PLGA)(n)-b-bPEI micelles in acidic microclimate for potential protein delivery application
Poly(lactide-co-glycolide) (PLGA) has most often been employed for the controlled release of protein formulations because of its safety profile with non-toxic degradation products. Nevertheless, such formulations have been plagued by a local acidic microenvironment and protein-polymer interactions,...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372690/ https://ncbi.nlm.nih.gov/pubmed/22405902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.02.024 |
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