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Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects
Dysregulated Notch signaling has been implicated in numerous human diseases, including a broad spectrum of cancers. Mutations in Notch1 are prevalent in T-cell acute lymphoblastic leukemia, and abnormal expression of different human Notch receptors contributes to B-cell tumors as well as cancers of...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372654/ https://ncbi.nlm.nih.gov/pubmed/22309842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2012.01.016 |
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