In vivo evaluation of the delivery and efficacy of a sirolimus-laden polymer gel for inhibition of hyperplasia in a porcine model of arteriovenous hemodialysis graft stenosis.

Synthetic arteriovenous (AV) hemodialysis grafts are plagued by hyperplasia resulting in occlusion and graft failure yet there are no clinically available preventative treatments. Here the delivery and degradation of a sirolimus-laden polymer gel was monitored in vivo by magnetic resonance imaging (...

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Detalhes bibliográficos
Main Authors: Terry, Christi M., Li, Li, Li, Huan, Zhuplatov, Ilya, Blumenthal, Donald K., Kim, Seong-Eun, Owen, Shawn C., Kholmovski, Eugene G., Fowers, Kirk D., Rathi, Ramesh, Cheung, Alfred K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372620/
https://ncbi.nlm.nih.gov/pubmed/22465391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.03.011
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