GEP100/Arf6 Is Required for Epidermal Growth Factor-Induced ERK/Rac1 Signaling and Cell Migration in Human Hepatoma HepG2 Cells

BACKGROUND: Epidermal growth factor (EGF) signaling is implicated in the invasion and metastasis of hepatoma cells. However, the signaling pathways for EGF-induced motility of hepatoma cells remain undefined. METHODOLOGY/PRINCIPAL FINDINGS: We found that EGF dose-dependently stimulated the migration...

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Detalhes bibliográficos
Main Authors: Hu, ZhenZhen, Du, Jun, Yang, Ling, Zhu, YiChao, Yang, Yu, Zheng, DaTong, Someya, Akimasa, Gu, Luo, Lu, Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372492/
https://ncbi.nlm.nih.gov/pubmed/22701712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038777
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