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Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung

Asthma pathogenesis is focused around conducting airways. The reasons for this focus have been unclear because it has not been possible to track the sites and timing of antigen uptake or subsequent antigen presentation to effector T cells. In this study, we use two-photon microscopy of the lung pare...

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Detalles Bibliográficos
Main Authors: Thornton, Emily E., Looney, Mark R., Bose, Oishee, Sen, Debasish, Sheppard, Dean, Locksley, Richard, Huang, Xiaozhu, Krummel, Matthew F.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371730/
https://ncbi.nlm.nih.gov/pubmed/22585735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112667
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