Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis

Variants associated with meconium ileus in cystic fibrosis (CF) were identified in 3,763 patients by GWAS. Five SNPs at two loci near SLC6A14 (min P=1.28×10(−12) at rs3788766), chr Xq23-24 and SLC26A9 (min P=9.88×10(−9) at rs4077468), chr 1q32.1 accounted for ~5% of the phenotypic variability, and w...

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Main Authors: Sun, Lei, Rommens, Johanna M, Corvol, Harriet, Li, Weili, Li, Xin, Chiang, Theodore, Lin, Fan, Dorfman, Ruslan, Busson, Pierre-François, Parekh, Rashmi V, Zelenika, Diana, Blackman, Scott, Corey, Mary, Doshi, Vishal, Henderson, Lindsay, Naughton, Kathleen, O'Neal, Wanda K, Pace, Rhonda G, Stonebraker, Jaclyn R, Wood, Sally D, Wright, Fred A, Zielenski, Julian, Clement, Annick, Drumm, Mitchell L, Boëlle, Pierre-Yves, Cutting, Garry R, Knowles, Michael R, Durie, Peter R, Strug, Lisa J
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371103/
https://ncbi.nlm.nih.gov/pubmed/22466613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2221
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