A Randomized, Double Blind, Placebo-Controlled Trial of Pioglitazone in Combination with Riluzole in Amyotrophic Lateral Sclerosis

BACKGROUND: Pioglitazone, an oral anti-diabetic that stimulates the PPAR-gamma transcription factor, increased survival of mice with amyotrophic lateral sclerosis (ALS). METHODS/PRINCIPAL FINDINGS: We performed a phase II, double blind, multicentre, placebo controlled trial of pioglitazone in ALS pa...

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Detalhes bibliográficos
Main Authors: Dupuis, Luc, Dengler, Reinhard, Heneka, Michael T., Meyer, Thomas, Zierz, Stephan, Kassubek, Jan, Fischer, Wilhelm, Steiner, Franziska, Lindauer, Eva, Otto, Markus, Dreyhaupt, Jens, Grehl, Torsten, Hermann, Andreas, Winkler, Andrea S., Bogdahn, Ulrich, Benecke, Reiner, Schrank, Bertold, Wessig, Carsten, Grosskreutz, Julian, Ludolph, Albert C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371007/
https://ncbi.nlm.nih.gov/pubmed/22715372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037885
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