X-Box Binding Protein 1 Is Essential for the Anti-Oxidant Defense and Cell Survival in the Retinal Pigment Epithelium

Damage to the retinal pigment epithelium (RPE) is an early event in the pathogenesis of age-related macular degeneration (AMD). X-box binding protein 1 (XBP1) is a key transcription factor that regulates endoplasmic reticulum (ER) homeostasis and cell survival. This study aimed to delineate the role...

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Detalhes bibliográficos
Main Authors: Zhong, Yimin, Li, Jingming, Wang, Joshua J., Chen, Chen, Tran, Julie-Thu A., Saadi, Anisse, Yu, Qiang, Le, Yun-zheng, Mandal, Md Nawajes A., Anderson, Robert E., Zhang, Sarah X.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371004/
https://ncbi.nlm.nih.gov/pubmed/22715395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038616
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