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Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment

Nitric oxide (NO) production by the vascular endothelium maintains an essential antiinflammatory, cytoprotective influence on the blood vessel wall. A key component of this activity is attributed to prevention of leukocyte–endothelial cell interactions, yet the underlying mechanisms remain unclear....

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Autors principals: Ahluwalia, Amrita, Foster, Paul, Scotland, Ramona S., McLean, Peter G., Mathur, Anthony, Perretti, Mauro, Moncada, Salvador, Hobbs, Adrian J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC337062/
https://ncbi.nlm.nih.gov/pubmed/14742866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0304264101
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